dNMF

In this project, we develop a computational framework to predict single-site micorstimulation effects using ensemble's resting state spiking activity in an alert monkey’s prefrontal cortex.

Extracting calcium traces from the neurons of mobile animals is a critical step in the study of the large-scale neuronal dynamics that govern behavior. Accurate activity extraction requires the correction of motion and movement-induced deformations as well as demixing of signals that may overlap spatially due to limitations in optical resolution. Here, we introduce a deformable non-negative matrix factorization (dNMF) framework that jointly optimizes registration with signal demixing.